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MCC950 sodium
CAS No. 256373-96-3
MCC950 sodium( CP-456773 sodium | CRID3 sodium salt | MCC-950 sodium | CP456773 sodium | CRID-3 sodium salt )
Catalog No. M13769 CAS No. 256373-96-3
MCC950 (CP-456773) is a potent, selective, small-molecule inhibitor of NLRP3 inflammasome with IC50 of 7.5 and 8.1 nM in BMDM and HMDM, respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 42 | In Stock |
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| 10MG | 68 | In Stock |
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| 25MG | 143 | In Stock |
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| 50MG | 237 | In Stock |
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| 100MG | 368 | In Stock |
|
| 200MG | 444 | In Stock |
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| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
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Biological Information
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Product NameMCC950 sodium
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NoteResearch use only, not for human use.
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Brief DescriptionMCC950 (CP-456773) is a potent, selective, small-molecule inhibitor of NLRP3 inflammasome with IC50 of 7.5 and 8.1 nM in BMDM and HMDM, respectively.
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DescriptionMCC950 (CP-456773) is a potent, selective, small-molecule inhibitor of NLRP3 inflammasome with IC50 of 7.5 and 8.1 nM in BMDM and HMDM, respectively, specifically inhibits activation of NLRP3, does not inhibit NLRC4, AIM2, TLR signalling or priming of NLRP3; blocks NLRP3 induced ASC oligomerization, does not block K+ efflux, Ca2+ flux or NLRP3-ASC interactions; reduces interleukin-1β (IL-1β) production in vivo and attenuates the severity of experimental autoimmune encephalomyelitis (EAE), rescues neonatal lethality in mouse model of CAPS and is active in ex vivo samples from individuals with Muckle-Wells syndrome.
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In Vitro——
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In Vivo——
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SynonymsCP-456773 sodium | CRID3 sodium salt | MCC-950 sodium | CP456773 sodium | CRID-3 sodium salt
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PathwayNF-κB
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TargetNOD
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RecptorNLRP3
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Research AreaInflammation/Immunology
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Indication——
Chemical Information
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CAS Number256373-96-3
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Formula Weight426.4618
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Molecular FormulaC20H23N2NaO5S
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Purity>98% (HPLC)
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SolubilityH2O: ≥ 30 mg/mL
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SMILESCC(C)(C1=COC(=C1)S(=O)(=O)[N-]C(=O)NC2=C3CCCC3=CC4=C2CCC4)O.[Na+]
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Chemical Name2-Furansulfonamide, N-[[(1,2,3,5,6,7-hexahydro-s-indacen-4-yl)amino]carbonyl]-4-(1-hydroxy-1-methylethyl)-, sodium salt (1:1)
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Coll RC, et al. Nat Med. 2015 Mar;21(3):248-55.
2. Krishnan SM, et al. Br J Pharmacol. 2016 Feb;173(4):752-65.
3. Baker PJ, et al. Eur J Immunol. 2015 Oct;45(10):2918-26.
4. Primiano MJ, et al. J Immunol. 2016 Sep 15;197(6):2421-33.
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MCC950 sodium
MCC950 (CP-456773) is a potent, selective, small-molecule inhibitor of NLRP3 inflammasome with IC50 of 7.5 and 8.1 nM in BMDM and HMDM, respectively.
-
MCC950
MCC950 (CP-456773) is a potent, selective, small-molecule inhibitor of NLRP3 inflammasome with IC50 of 7.5 and 8.1 nM in BMDM and HMDM, respectively.
